Wan-Ning Li, Meng-Hsing Wu, and Shaw-Jenq Tsai
Chronic inflammation is the cause and effect in the pathogenesis of endometriosis. Characterized as an imbalance of various kinds of cytokines and deficient immune-surveillance in the peritoneal cavity, endometriosis creates its own system to maintain the survival of endometriotic cells outside of the uterus. Characteristics of the cells present in the microenvironment including immune cells and endometriotic cells have been changed by cytokines and other protein molecules, which are the critical keys that determine the development of the disease. In this review, we will focus on the effects from the inflammation-related factors on the phenotypic changes in cells in the pathogenesis of endometriosis to discuss.
Key Words: chronic inflammation, endometriosis, proinflammatory cytokines, prostaglandins
Adaptive Medicine Adaptive Medicine 10(1): 1-9, 2018 DOI: 10.4247/AM.2018.ABI197
